Led by Professor Ke Du, we are an interdisciplinary research team dedicated to address global challenges including health care, manufacturing, and cleaner water by combining fundamental studies of biomolecules at single molecule level with novel nanostructured materials and automated microfluidic systems.
In this project, we are exploring point-of-care devices for the detection of viral RNA in blood, such as Ebola and Zika. We pursue not only fluorescence detection, but also Raman and electrical detection. A high sensitivity is achieved thereby avoiding nucleic acid amplification.
P. Qin et al. "Rapid and fully microfluidic Ebola virus detection with CRISPR-Cas13a." ACS Sensors.
4 (2019): 1048-1054.
K. Du et al. "Microfluidic system for detection of viral RNA in blood using a barcode fluorescence reporter and a photocleavable capture probe." Analytical Chemistry 89.22 (2017): 12433-12440.
K. Du et al. "Multiplexed efficient on-chip sample preparation and sensitive amplification-free detection of Ebola virus." Biosensors and Bioelectronics. 91 (2017): 489-496.
K. Du et al. "Superhydrophobic waveguide: liquid-core air-cladding waveguide platform for optofluidics." Applied Physics Letters. 113 (2018): 143701.
In this project, we are developing nanomanufacturing techniques that can pattern nanostructures with a large surface area and high uniformity. Examples include soft stencil nanolithography for high aspect ratio, multi-scale hierarchical nanostructures patterning.
K. Du et al. "Self-formation of polymer nanostructures in plasma etching: mechanisms and applications." Journal of Micromechanics and Microengineering. 28 (2018): 014006.
K. Du et al. "Selective hierarchical patterning of silicon nanostructures via soft nanostencil lithography." Nanotechnology 28.46 (2017): 465303.
K. Du et al. "Wafer-Scale pattern transfer of metal nanostructures on polydimethylsiloxane (PDMS) substrates via holographic nanopatterns." ACS Applied Materials & Interfaces. 4.10 (2012): 5505-5514.
J. Ding et al. "Transfer patterning of large-area graphene nanomesh via holographic lithography and plasma etching." Journal of Vacuum Science & Technology B. 32.6 (2014): 06FF01.
In this project, we are investigating materials properties that can be controlled by temperature, surface chemistry, and pH value. Examples include porous oxide materials which are formed by the Kirkendall Effect at the nanoscale.
X. Chen et al. "Experimental and theoretical study on the microparticle trapping and release in a deformable nano-sieve channel." Nanotechnology. in press.
A. El Mel et al. "Electron beam nanosculpting of kirkendall oxide nanochannels." ACS Nano. 8.2 (2014): 1854-1861.
K. Du et al. "Fabrication of polymer nanowires via maskless O2 plasma etching." Nanotechnology 25.16 (2014): 165301.
Y. Jiang et al. "Nanotexturing of conjugated polymers via one-step maskless oxygen plasma etching for enhanced tunable wettability." Langmuir. 33.27 (2017): 6885-6894.